Espinoza Z Milagros, Ruiz F Nelina, Barrios Emilia, Reigosa Aldo, Leal H Ulises, González Julio César
Centro de Investigaciones Médicas y Biotecnológicas de la Universidad de Carabobo (CMBUC), Facultad de Ciencias de la Salud, Universidad de Carabobo, Venezuela.
Rev Med Chil. 2009 Sep;137(9):1179-86.
Insulin plays a determinant role in the individual metabolic profile. Obesity, the most common cause of insulin resistance (IR), can be diagnosed by body mass index (BMI). Waist circumference (WC), specifically, measures accumulation of abdominal fat. The cardiovascular risk of an individual is strongly related to a combination of abdominal obesity with hypertriglyceridemia or hypertriglyceridemic waist (HTW).
To assess the metabolic profile of cardiovascular risk and RI according to BMI, WC and HTW in adult patients.
Weight, height, BMI, blood pressure (BP), WC, HTW, blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and insulin were assessed and IR calculated by the homeostasis model assessment (HOMA) in 63 females aged 46+/-11 years and 12 males aged 4 7+/- 10 years.
Differences in weight, WC, BP, lipids, glucose, insulin and HOMA, were observed as BMI increased. When patients were grouped according to WC, there were significant differences only in systolic pressure, triglycerides, insulin and HOMA. Individuals with HTW had a more adverse metabolic profile than those without HTW or with only high WC. A multiple regression equation determined that body mass index, total cholesterol and diastolic blood pressure were independent predictors of insulin resistance.
Patients with HTW displayed an unfavorable cardiac risk profile.
胰岛素在个体代谢状况中起决定性作用。肥胖是胰岛素抵抗（IR）最常见的原因，可通过体重指数（BMI）进行诊断。具体而言，腰围（WC）可测量腹部脂肪的堆积情况。个体的心血管风险与腹部肥胖合并高甘油三酯血症或高甘油三酯血症腰围（HTW）密切相关。
根据BMI、WC和HTW评估成年患者心血管风险和胰岛素抵抗的代谢状况。
对63名年龄为46±11岁的女性和12名年龄为47±10岁的男性进行体重、身高、BMI、血压（BP）、WC、HTW、血糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和胰岛素的评估，并通过稳态模型评估（HOMA）计算胰岛素抵抗。
随着BMI的增加，体重、WC、BP、血脂、血糖、胰岛素和HOMA均出现差异。当根据WC对患者进行分组时，仅收缩压、甘油三酯、胰岛素和HOMA存在显著差异。与无HTW或仅有高WC的个体相比，有HTW的个体代谢状况更差。多元回归方程确定体重指数、总胆固醇和舒张压是胰岛素抵抗的独立预测因素。
有HTW的患者呈现出不利的心脏风险状况。
