人类 TAP3/SEC14L4 基因的可变剪接和基因多态性。
Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene.
机构信息
Department of Pediatric Endocrinology and Diabetology, University Children's Hospital, Bern, Switzerland.
出版信息
Mol Biol Rep. 2010 Oct;37(7):3503-8. doi: 10.1007/s11033-009-9943-2. Epub 2009 Dec 10.
Three closely related human SEC14p-like proteins (hTAP1, hTAP2, hTAP3, or SEC14L2, SEC14L3, SEC14L4, respectively) have been described that are related to the Saccharomyces cerevisiae SEC14 protein. These proteins may participate in intracellular lipid transport and influence regulatory lipid-dependent events. Here we report the isolation of an alternatively spliced hTAP3 cDNA and a polymorphism within the coding region of the hTAP3/SEC14L4 gene.
已经描述了三种密切相关的人类 SEC14p 样蛋白（hTAP1、hTAP2、hTAP3 或 SEC14L2、SEC14L3、SEC14L4，分别），它们与酿酒酵母 SEC14 蛋白有关。这些蛋白质可能参与细胞内脂质运输并影响调节脂质依赖性事件。在这里，我们报告了一种 hTAP3 剪接异构体 cDNA 的分离以及 hTAP3/SEC14L4 基因编码区的多态性。
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