Zingg Jean-Marc, Azzi Angelo, Meydani Mohsen
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Nutr Rev. 2008 Jul;66(7):406-14. doi: 10.1111/j.1753-4887.2008.00050.x.
Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.
参与维生素E摄取、分布、代谢及分子作用的基因多态性，可能是维生素E补充剂发挥保护作用的重要决定因素。触珠蛋白2-2多态性与氧自由基产生增加相关，并会降低维生素E和维生素C的水平；补充维生素E可预防由此导致的心血管疾病风险升高。
