Soloviev Mikhail
School of Biological Sciences, Royal Holloway University of London, TW20 0EX, Egham, Surrey, UK.
Methods Mol Biol. 2010;615:3-9. doi: 10.1007/978-1-60761-535-4_1.
The term "peptidomics" can be defined as the systematic analysis of the peptide content within a cell, organelle, tissue or organism. The science of peptidomics usually refers to the studies of naturally occurring peptides. Another meaning refers to the peptidomics approach to protein analysis. An ancient Roman strategy divide et impera (divide and conquer) reflects the essence of peptidomics. Most effort in this field is spent purifying and dividing the peptidomes, which consist of tens, hundreds or sometimes thousands of functional peptides, followed by their structural and functional characterisation. This chapter introduces the concept of peptidomics, outlines the range of methodologies employed and describes key targets - the peptide groups which are often sought after in such studies.
“肽组学”一词可定义为对细胞、细胞器、组织或生物体中肽含量的系统分析。肽组学这门科学通常指对天然存在的肽的研究。另一种含义是指用于蛋白质分析的肽组学方法。古罗马的“分而治之”策略体现了肽组学的精髓。该领域的大部分工作都花在纯化和区分肽组上，肽组由数十种、数百种甚至有时数千种功能性肽组成，随后对其进行结构和功能表征。本章介绍肽组学的概念，概述所采用的方法范围，并描述关键目标——此类研究中经常追寻的肽组。
