Yoshioka I, Sakurai M, Namai A, Kawamura T
Department of Cardiovascular Surgery, National Hospital Organization Sendai Medical Center, Sendai, Japan.
Thorac Cardiovasc Surg. 2009 Dec;57(8):464-7. doi: 10.1055/s-0029-1186069.
Postoperative atrial fibrillation (AF) is the most common complication after coronary artery bypass grafting (CABG). We have reported that the intra- and perioperative administration of landiolol has a preventive effect on postoperative AF in the early postoperative period after CABG surgery. The purpose of this study was to investigate the prophylactic effect of postoperative treatment with carvedilol following landiolol against postoperative AF.
We reviewed all patients who underwent CABG from December 2005 and February 2009. Fifty-three patients underwent scheduled isolated CABG and were divided two groups; carvedilol group (n = 31), and control group (n = 22). Incidences of postoperative AF were noted.
There was no statistical difference between the two groups with regard to the occurrence of AF after CABG. The maximum ventricular rate of AF was significantly lower in the carvedilol group than in the control group. All patients with AF in the control group needed treatment for tachycardia, but this was not necessary in the carvedilol group.
Postoperative treatment with carvedilol following landiolol has the effect of preventing tachycardia during AF after coronary artery bypass grafting.
术后房颤（AF）是冠状动脉旁路移植术（CABG）后最常见的并发症。我们曾报道，术中和围手术期使用兰地洛尔对CABG术后早期的术后房颤有预防作用。本研究的目的是探讨在使用兰地洛尔后，术后使用卡维地洛对术后房颤的预防作用。
我们回顾了2005年12月至2009年2月期间所有接受CABG的患者。53例患者接受了择期单纯CABG，并被分为两组；卡维地洛组（n = 31）和对照组（n = 22）。记录术后房颤的发生率。
两组在CABG后房颤的发生方面无统计学差异。卡维地洛组房颤时的最大心室率显著低于对照组。对照组所有房颤患者均需要治疗心动过速，但卡维地洛组则无需如此。
在使用兰地洛尔后，术后使用卡维地洛对冠状动脉旁路移植术后房颤期间的心动过速有预防作用。
