Weryńska Bozena, Kosacka Monika, Gołecki Marcin, Jankowska Renata
Pneumonol Alergol Pol. 2009;77(6):500-6.
Leptin, protein taking part in body mass regulation, might play a role in cancer cachexia development. The aim of the study was to measure leptin serum levels in cachectic, non-cachectic lung cancer patients, healthy controls and to correlate leptin concentration with nutritional status markers.
40 lung cancer patients were enrolled into the study: 20 with cachexia, 20 without cachexia, and 10 healthy controls. Leptin serum concentration, body mass, BMI, arm circumference and skin triceps fold thickness were measured in each subject.
Serum leptin level in cachectic cancer patients was significantly lower than in non-cachectic and healthy controls. Leptin concentration correlated with body mass, arm circumference and skin triceps fold thickness.
Cachectic lung cancer patients have significantly lower serum leptin concentrations than non-cachectic patients and healthy controls which may suggest, that leptin does not play an important role in cancer cachexia development. Leptin levels positively correlate with good nutritional status markers. Non-cachectic lung cancer patients have similar leptin serum levels as healthy controls.
瘦素是一种参与体重调节的蛋白质，可能在癌症恶病质的发展中起作用。本研究的目的是测量恶病质肺癌患者、非恶病质肺癌患者及健康对照者的血清瘦素水平，并将瘦素浓度与营养状况指标进行关联。
40例肺癌患者纳入本研究，其中20例患有恶病质，20例无恶病质，另有10例健康对照者。测量了每位受试者的血清瘦素浓度、体重、体重指数、上臂围和肱三头肌皮褶厚度。
恶病质癌症患者的血清瘦素水平显著低于非恶病质患者和健康对照者。瘦素浓度与体重、上臂围和肱三头肌皮褶厚度相关。
恶病质肺癌患者的血清瘦素浓度显著低于非恶病质患者和健康对照者，这可能表明瘦素在癌症恶病质的发展中不起重要作用。瘦素水平与良好的营养状况指标呈正相关。非恶病质肺癌患者的血清瘦素水平与健康对照者相似。
