Department of Nephrology, University of Messina, Messina, Italy.
J Nephrol. 2009 Nov-Dec;22 Suppl 14:60-3.
Recently the importance in nephrology of phosphorus as phosphate has been highlighted by chronic renal failure patients, in whom the toxic effect of phosphate is widely acknowledged, given the association of phosphate serum level with cardiovascular risk. This association is not limited to chronic renal failure and hemodialysis patients as high serum phosphate. Recently high serum phosphate levels were associated with increased risk for cardiovascular disease in subjects free from chronic kidney disease, and cardiovascular disease as well, and with progression of atherosclerosis. It is useful to know the history of phosphorus from its discovery in 1669, because that history gives us more evidence to better understand the negative and/or toxic effects of high phosphate serum levels and to identify phosphorus as a physiologically crucial anion.
最近，磷作为磷酸盐在肾脏病学中的重要性已经引起了慢性肾衰竭患者的关注，因为人们普遍认识到磷酸盐血清水平与心血管风险之间存在关联。这种关联不仅限于慢性肾衰竭和血液透析患者，因为高血清磷酸盐水平与心血管疾病风险增加有关。最近，在没有慢性肾脏病的受试者中，高血清磷酸盐水平与心血管疾病以及动脉粥样硬化进展的风险增加有关。了解磷从 1669 年被发现以来的历史是很有用的，因为这段历史为我们提供了更多的证据，有助于我们更好地理解高磷酸盐血清水平的负面和/或毒性作用，并将磷确定为一种生理上至关重要的阴离子。
