Centre for Surface Chemistry and Catalysis, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, Box 2461, 3001 Leuven, Belgium.
Chemistry. 2010 Jan 18;16(3):1061-7. doi: 10.1002/chem.200901659.
The quickly developing field of "click" chemistry would undoubtedly benefit from the availability of an easy and efficient technology for product purification to reduce the potential health risks associated with the presence of copper in the final product. Therefore, solvent-resistant nanofiltration (SRNF) membranes have been developed to selectively separate "clicked" polymers from the copper catalyst and solvent. By using these solvent-stable cross-linked polyimide membranes in diafiltration, up to 98 % of the initially present copper could be removed through the membrane together with the DMF solvent, the polymer product being almost completely retained. This paper also presents the first SRNF application in which the catalyst permeates through the membrane and the reaction product is retained.
“点击”化学这一快速发展的领域无疑将受益于易于使用且高效的产物纯化技术，以降低最终产物中铜存在带来的潜在健康风险。因此，开发了耐溶剂纳滤（SRNF）膜，以从铜催化剂和溶剂中选择性地分离“点击”聚合物。在渗滤中使用这些溶剂稳定的交联聚酰亚胺膜，最初存在的 98%的铜可以与 DMF 溶剂一起通过膜去除，聚合物产物几乎完全被保留。本文还介绍了首次将催化剂透过膜而反应产物被截留的 SRNF 应用。
