从间充质干细胞中发现一种新的有效小分子神经元分化。
Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell.
机构信息
Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
出版信息
J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558.
PMID:20014867
Abstract
A new synthetic small molecule, compound 1, which induced a neuronal differentiation from mesenchymal stem cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.
摘要
一种新的合成小分子化合物 1 被鉴定出来，它能有效地诱导间充质干细胞（MSCs）向神经元分化。此外，1 诱导分化的细胞表现出神经电生理和胆碱能神经元特性。
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