健康妊娠中循环和蜕膜 Th17 细胞水平。
Circulating and decidual Th17 cell levels in healthy pregnancy.
机构信息
Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
出版信息
Am J Reprod Immunol. 2010 Feb;63(2):104-9. doi: 10.1111/j.1600-0897.2009.00771.x. Epub 2009 Dec 15.
PROBLEM
The Th1/Th2 paradigm has recently been reconstituted to include a third population, Th17 cells. It has been reported that Th2 type immunity is predominantly present in normal pregnancy. However, the level of Th17 cells during pregnancy is still unclear. We investigated the level of peripheral Th17 cells in healthy pregnancy subjects.
METHOD
of study To evaluate the levels of Th17 cells, we investigated the proportion of peripheral blood mononuclear cells that produced IL-17 in the first, second, and third trimester pregnancy subjects using flow cytometry. We further studied the proportion of decidual lymphocytes that produced IL-17 in early pregnant subjects.
RESULTS
Most of the IL-17-producing cells were CD4(+) T cells. The number of circulating Th17 cells did not change during pregnancy. In a paired t-test of early normal pregnant subjects, the proportion of IL-17(+) decidual lymphocytes was significantly higher than that of peripheral blood lymphocytes.
CONCLUSION
Th17 levels in peripheral blood lymphocytes do not change during normal pregnancy.
问题
最近，Th1/Th2 细胞模式已被重新构建，包括第三个群体 Th17 细胞。据报道，Th2 型免疫主要存在于正常妊娠中。然而，妊娠期间 Th17 细胞的水平仍不清楚。我们研究了健康妊娠妇女外周血 Th17 细胞的水平。
方法
为了评估 Th17 细胞的水平，我们使用流式细胞术检测了妊娠第一、二、三期中外周血单个核细胞产生 IL-17 的比例。我们进一步研究了早孕妇女中产生 IL-17 的蜕膜淋巴细胞的比例。
结果
大多数产生 IL-17 的细胞为 CD4+T 细胞。妊娠期间循环 Th17 细胞的数量没有变化。在配对 t 检验中，早期正常妊娠妇女的蜕膜淋巴细胞中 IL-17+的比例明显高于外周血淋巴细胞。
结论
正常妊娠期间外周血淋巴细胞中的 Th17 水平没有变化。
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