Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Am J Reprod Immunol. 2010 Jul 1;64(1):4-11. doi: 10.1111/j.1600-0897.2010.00812.x. Epub 2010 Mar 4.
Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.
IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.
IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.
IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.
Th17 细胞是辅助性 T 细胞的一个新亚群，作为促炎细胞因子的产生细胞而受到关注。然而，Th17 细胞如何影响妊娠结局仍不清楚。我们研究了人自然流产中 IL-17 产生细胞的表达。
通过免疫组化和流式细胞术分析正常妊娠、难免流产和稽留流产患者蜕膜组织中 IL-17 的表达。
IL-17+细胞在蜕膜中积聚，并在自然流产患者的蜕膜 CD4+T 细胞和少数蜕膜 CD8+T 细胞中检测到。涉及活动性生殖器出血的难免流产病例中蜕膜 IL-17+细胞的数量明显高于正常妊娠病例（P<0.05）。另一方面，难免流产病例与正常妊娠患者之间蜕膜 IL-17+细胞的数量无显著差异。此外，IL-17+细胞的数量与自然流产病例中中性粒细胞的数量呈正相关。
IL-17+细胞可能参与流产晚期的炎症诱导，但不参与流产早期。
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