Peninsula Medical School, University of Exeter, Exeter, UK.
Health Technol Assess. 2009 Dec;13(61):1-75, iii. doi: 10.3310/hta13610.
To search for, review and synthesise studies of the effectiveness and cost-effectiveness of weight management schemes for the under fives.
MEDLINE [Ovid], MEDLINE In-Process [Ovid], EMBASE [Ovid], CAB [Ovid], Health Management Information Consortium [Ovid], The Cochrane Database of Systematic Reviews, Cochrane Register of Controlled Trials, Science Citation Index Expanded [Web of Science], Conference Proceedings Citation Index [The Web of Science], Database of Abstract Reviews [CRD; Centre for Reviews and Dissemination], HTA [CRD], PsycINFO [Ebsco], NHS CRD. These databases were searched from 1990 to February 2009. Supplementary internet searches were additionally conducted.
Relevant clinical effectiveness studies were identified in two stages. Titles and abstracts returned by the search strategy were examined independently by three researchers and screened for possible inclusion. Disagreements were resolved by discussion. Full texts of the identified studies were obtained. Three researchers examined these independently for inclusion or exclusion, and disagreements were again resolved by discussion.
One of the randomised controlled trials (RCTs) was from the UK. It measured the effects of a physical activity intervention for children in nurseries combined with home-based health education for their parents; this was compared to usual care. The main outcome measure was body mass index (BMI); secondary measures were weight and physical activity. At the 12-month follow-up, no statistically significant differences were found between the groups on any measure. However, a trend, favouring the intervention, was found for BMI and weight. The other two RCTs were from the USA. The larger trial investigated the effects of a combined preschool and home intervention in African American and Latino communities. Nutrition education and physical activity programmes were aimed at under fives in preschool. The home component consisted of related health education and homework for the parents, who received a small financial reward on completion. The 1- and 2-year results for the African American sites showed a significantly slower rate of increase in BMI than for results at baseline, for the intervention group than for the control group. However, in the Latino communities no such differences were found. The second US trial was a much smaller home-based parental education programme in Native American communities in the USA and Canada. The intervention consisted of a parental skills course for parents to improve their children's diet and physical activity. This was compared with a course providing skills to improve child behaviour. Follow-up was at 16 weeks and showed no significant differences between groups in BMI.
No controlled trials addressing the issue of treating obesity or evidence of cost-effectiveness studies in the under fives' population were found. From the three prevention studies, apart from the larger US trial, the interventions showed no statistically significant differences in BMI and weight between the intervention and control groups (although there was some evidence of positive trends for BMI and weight). It should also be noted that these conclusions are based on only three dissimilar studies, thereby making the drawing of firm conclusions difficult. Research is urgently needed in further well-designed UK-based RCTs of weight management schemes aimed at the prevention of obesity, that combine with cost-effectiveness studies targeted at preschool children with long-term follow-up.
搜索、评价并综合评估针对五岁以下儿童的体重管理计划的有效性和成本效益。
MEDLINE [Ovid]、MEDLINE In-Process [Ovid]、EMBASE [Ovid]、CAB [Ovid]、健康管理信息联合会 [Ovid]、Cochrane 系统评价数据库、Cochrane 对照试验登记册、科学引文索引扩展版 [Web of Science]、会议录引文索引 [Web of Science]、数据库文摘评论 [CRD; 中心评论与传播]、卫生技术评估 [CRD]、PsycINFO [Ebsco]、NHS CRD。这些数据库从 1990 年到 2009 年 2 月进行了检索。此外,还进行了额外的互联网补充检索。
分两个阶段确定了相关的临床有效性研究。通过搜索策略返回的标题和摘要由三位研究人员独立进行检查,并筛选出可能纳入的研究。意见分歧通过讨论解决。获得了确定研究的全文。三位研究人员独立评估这些研究的纳入或排除标准,再次通过讨论解决分歧。
其中一项随机对照试验(RCT)来自英国。它测量了针对托儿所儿童的身体活动干预措施与针对其父母的基于家庭的健康教育相结合的效果;这与常规护理进行了比较。主要结局指标是体重指数(BMI);次要结局指标是体重和身体活动。在 12 个月的随访中,两组在任何指标上均未发现统计学上的显著差异。然而,在 BMI 和体重方面,干预组存在有利趋势。另外两项 RCT 来自美国。较大的试验调查了在非裔美国人和拉丁裔社区中进行的学前和家庭综合干预措施的效果。营养教育和身体活动计划针对学龄前儿童。家庭部分包括针对家长的相关健康教育和家庭作业,完成后家长可以获得少量经济奖励。在非裔美国人站点的 1 年和 2 年结果中,干预组的 BMI 增长率明显低于基线时的对照组。然而,在拉丁裔社区中,并未发现这种差异。第二项美国试验是在美国和加拿大的美洲原住民社区中进行的一项规模较小的家庭为基础的家长教育计划。干预措施包括为父母提供改善孩子饮食和身体活动的技能课程。这与提供改善儿童行为技能的课程进行了比较。随访时间为 16 周,两组间 BMI 无显著差异。
未发现针对五岁以下儿童肥胖治疗或成本效益研究的对照试验。在三项预防研究中,除了较大的美国试验外,干预组与对照组之间的 BMI 和体重在统计学上没有显著差异(尽管 BMI 和体重有一些积极趋势的证据)。还应该注意的是,这些结论仅基于三项不同的研究,因此难以得出明确的结论。迫切需要在英国进行进一步的、设计良好的、针对学龄前儿童的体重管理计划的 RCT 研究,该计划针对肥胖预防,结合针对长期随访的学龄前儿童的成本效益研究。