Becker François
Service d'angiologie et d'hémostase, Hôpitaux universitaires de Genève, 24 rue Micheli-du-Crest, Genève, CH 1211, Suisse.
Presse Med. 2010 Feb;39(2):249-53. doi: 10.1016/j.lpm.2009.04.014. Epub 2009 Dec 16.
Abdominal aortic disease in women is associated with atheromatous processes much more often than with inflammatory arterial diseases (such as Takayasu or Horton). Intramural hematomas and atheromatous ulcers of the aorta, albeit rare, affect as many women as men and have variable outcomes: some are resolved with heparin treatment, and others are fatal. Atherosclerotic stenoses and occlusions limited to the level of the aortoiliac bifurcation are increasingly prevalent and difficult to treat in young women, in part because of their addiction to smoking. After being more or less ignored for a long time, the particularity of atheromatous abdominal aortic aneurysms (AAA) in women is now being recognized. AAA in women are less frequent than in men, but grow faster and have a higher risk of rupture; moreover, cardiovascular disease is generally detected and managed less often in women. Overall mortality from AAA in women is similar to that of breast cancer. The two major risk factors for AAA are, as in men, a direct family history of AAA and smoking. The diagnostic standards for AAA, the criteria for defining progression, and the indications for surgery are probably not the same as in men, and the smaller initial caliber of women's aortas must be taken into account. Most guidelines today recommend ultrasound screening for AAA for women older than 50 years with a family history (in a 1(st)degree relative), women aged 60-75 years who are hypertensive or smoke, and smokers older than 75 years without serious comorbidity and with a life expectancy essentially normal for their age. Monitoring patients with a small AAA (anteroposterior diameter < 40-45 mm) must not be limited only to the aneurysm, but must also include comprehensive management to eliminate modifiable risk factors and thus to reduce cardiovascular and surgical risk (by better preparing the patient for this possibility) as well as to slow the progression of the aneurysm and decrease the risk of its rupture.
女性腹主动脉疾病与动脉粥样硬化过程的关联比与炎症性动脉疾病(如高安动脉炎或霍顿病)更为常见。主动脉壁内血肿和动脉粥样硬化性溃疡虽然罕见,但在女性和男性中的发病率相同,且预后各异:有些通过肝素治疗可得到缓解,而有些则会致命。局限于主-髂动脉分叉水平的动脉粥样硬化性狭窄和闭塞在年轻女性中越来越普遍且难以治疗,部分原因是她们吸烟成瘾。在长期或多或少被忽视之后,女性动脉粥样硬化性腹主动脉瘤(AAA)的特殊性现在正在得到认可。女性AAA的发病率低于男性,但生长速度更快,破裂风险更高;此外,女性中心血管疾病的检测和管理通常较少。女性AAA的总体死亡率与乳腺癌相似。与男性一样,AAA的两个主要危险因素是AAA的直系家族史和吸烟。AAA的诊断标准、定义进展的标准以及手术指征可能与男性不同,必须考虑到女性主动脉初始管径较小的情况。如今,大多数指南建议对有家族史(一级亲属)的50岁以上女性、60 - 75岁的高血压或吸烟女性以及75岁以上无严重合并症且预期寿命基本与其年龄相符的吸烟女性进行AAA超声筛查。对小AAA(前后径<40 - 45毫米)患者的监测不应仅局限于动脉瘤,还必须包括综合管理,以消除可改变的危险因素,从而降低心血管和手术风险(通过让患者更好地为此做好准备),减缓动脉瘤的进展并降低其破裂风险。