Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.
Trends Endocrinol Metab. 2010 Mar;21(3):166-73. doi: 10.1016/j.tem.2009.11.004. Epub 2009 Dec 16.
Thyroid hormone influences diverse metabolic pathways important in lipid and glucose metabolism, lipolysis and regulation of body weight. Recently, it has been recognized that thyroid hormone receptor interacts with transcription factors that predominantly respond to nutrient signals including the peroxisome proliferator-activated receptors, liver X receptor and others. Crosstalk between thyroid hormone signaling and these nutrient responsive factors occurs through a variety of mechanisms: competition for retinoid X receptor heterodimer partners, DNA binding sites and transcriptional cofactors. This review focuses on the mechanisms of interaction of thyroid hormone signaling with other metabolic pathways and the importance of understanding these interactions to develop therapeutic agents for treatment of metabolic disorders, such as dyslipidemias, obesity and diabetes.
甲状腺激素影响多种代谢途径,这些途径在脂质和葡萄糖代谢、脂肪分解以及体重调节中起着重要作用。最近,人们已经认识到甲状腺激素受体与转录因子相互作用,这些转录因子主要对营养信号做出反应,包括过氧化物酶体增殖物激活受体、肝 X 受体等。甲状腺激素信号与这些营养反应因子之间的串扰通过多种机制发生:与视黄酸 X 受体异二聚体伴侣、DNA 结合位点和转录共因子的竞争。本综述重点介绍了甲状腺激素信号与其他代谢途径相互作用的机制,以及了解这些相互作用对于开发治疗代谢紊乱(如血脂异常、肥胖和糖尿病)的治疗药物的重要性。