一种甲状腺激素反应性基因的产物与甲状腺激素受体相互作用。
The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors.
作者信息
Thompson C C, Bottcher M C
机构信息
Department of Neuroscience, Johns Hopkins University School of Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8527-32. doi: 10.1073/pnas.94.16.8527.
Abstract
Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thyroid hormone. By identifying proteins that interact with the hr gene product (Hr), we find that Hr interacts directly and specifically with thyroid hormone receptor (TR)-the same protein that regulates its expression. Unlike previously described receptor-interacting factors, Hr associates with TR and not with retinoic acid receptors (RAR, RXR). Hr can act as a transcriptional repressor, suggesting that its interaction with TR is part of a novel autoregulatory mechanism.
摘要
甲状腺激素是中枢神经系统（CNS）发育的关键调节因子，通过核受体作用来调节特定基因的表达。在发育中的中枢神经系统中，大鼠无毛（hr）基因的转录受到甲状腺激素的高度上调；我们在此表明hr是由甲状腺激素直接诱导的。通过鉴定与hr基因产物（Hr）相互作用的蛋白质，我们发现Hr直接且特异性地与甲状腺激素受体（TR）相互作用——TR正是调节其表达的同一种蛋白质。与先前描述的受体相互作用因子不同，Hr与TR结合，而不与视黄酸受体（RAR、RXR）结合。Hr可作为转录抑制因子，这表明它与TR的相互作用是一种新型自调节机制的一部分。
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Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.人甲状腺激素受体β与转录因子TFIIB的相互作用可能介导甲状腺激素对靶基因的去抑制和激活。
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