米库利茨病和库特纳肿瘤的临床病理相似性。
Clinicopathologic similarities between Mikulicz disease and Küttner tumor.
机构信息
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
出版信息
Am J Otolaryngol. 2010 Nov-Dec;31(6):429-34. doi: 10.1016/j.amjoto.2009.08.002. Epub 2009 Oct 31.
PURPOSE
Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. Küttner tumor (KT) is also reported to be an IgG(4)-related disease. In this study, we examined the clinicopathologic and serologic findings in MD (39 patients) and KT (6 patients) and attempted to discern the similarities between MD and KT.
MATERIALS AND METHODS
We diagnosed 39 patients with MD and 6 patients with KT. We analyzed the clinicopathologic and serologic findings (IgG subclasses) in 39 patients with MD and 6 patients with KT. Submandibular and labial salivary gland specimens obtained from patients with MD and KT were stained with anti-IgG(4) antibodies.
RESULTS
The mean IgG(4) concentration (±SD) was 931.1 ± 796.2 mg/dL in patients with MD and 756.2 ± 449.2 mg/dL in patients with KT. Abundant infiltration of IgG(4)-positive plasmacytes into the salivary glands was observed in both patients with MD and patients with KT.
CONCLUSION
The serologic and histopathologic findings in MD and KT are very similar, and these 2 conditions may be IgG(4)-related systemic diseases.
目的
最近的研究表明，米库利茨病（MD）与干燥综合征不同，是一种免疫球蛋白 G（IgG）（4）相关的系统性疾病。库特尼肿瘤（KT）也被报道为一种 IgG（4）相关疾病。在本研究中，我们检查了 MD（39 例）和 KT（6 例）的临床病理和血清学发现，并试图辨别 MD 和 KT 之间的相似性。
材料和方法
我们诊断了 39 例 MD 患者和 6 例 KT 患者。我们分析了 39 例 MD 患者和 6 例 KT 患者的临床病理和血清学（IgG 亚类）发现。从 MD 和 KT 患者的颌下腺和唇腺标本中，用抗 IgG（4）抗体染色。
结果
MD 患者的 IgG（4）浓度（平均值±SD）为 931.1±796.2mg/dL，KT 患者为 756.2±449.2mg/dL。在 MD 和 KT 患者的唾液腺中都观察到大量 IgG（4）阳性浆细胞浸润。
结论
MD 和 KT 的血清学和组织病理学发现非常相似，这两种情况可能是 IgG（4）相关的系统性疾病。
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