喉舌骨韧带的年龄相关性变化：基于组织病理学研究的功能意义。
Age-related changes in the hyoepiglottic ligament: functional implications based on histopathologic study.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Am J Otolaryngol. 2010 Nov-Dec;31(6):448-52. doi: 10.1016/j.amjoto.2009.08.003. Epub 2009 Oct 9.
PURPOSE
The study aimed to identify age-related changes in the hyoepiglottic ligament associated with function of the epiglottis during swallowing and respiration.
MATERIALS AND METHODS
Normal postmortem laryngeal tissue samples were obtained at autopsy from 20 individuals with no history of laryngeal disease. The subjects were divided into 2 groups: those aged 81-91 years (elderly group, n = 11) and those aged 31-48 years (non-elderly group, n = 9). Specimens were subjected to Elastica van Gieson and hematoxylin-eosin staining, and characteristics of the hyoepiglottic ligament were compared between groups.
RESULTS
The hyoepiglottic ligament extended from the epiglottis to both lingual muscles and the hyoid bone (pars lingualis and pars hyoideus). The numbers of muscle fibers (P < .001), collagenous fibers (P < .01), and elastic fibers (P < .001) were significantly decreased in the elderly group in comparison to those in the non-elderly group.
CONCLUSION
Age-related changes in the hyoepiglottic ligament appear to be associated with aspiration, obstructive sleep apnea syndrome, and acquired laryngomalacia in the elderly.
目的
本研究旨在探讨与吞咽和呼吸时会厌功能相关的舌骨-会厌韧带随年龄变化的特征。
材料与方法
对 20 例无喉部疾病史的尸检喉组织标本进行研究，根据年龄分为 2 组：81-91 岁（老年组，n=11）和 31-48 岁（非老年组，n=9）。对标本进行弹力纤维 Van Gieson 染色和苏木精-伊红染色，比较两组舌骨-会厌韧带的特征。
结果
舌骨-会厌韧带从会厌延伸至两侧的舌肌和舌骨（舌骨体部和舌骨下部）。与非老年组相比，老年组的肌纤维数量（P<0.001）、胶原纤维数量（P<0.01）和弹性纤维数量（P<0.001）显著减少。
结论
与年龄相关的舌骨-会厌韧带变化可能与老年人的误吸、阻塞性睡眠呼吸暂停综合征和获得性喉软化有关。
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