蛋白质折叠：粘性N17加速亨廷顿蛋白堆积。 - Suppr

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Protein folding: sticky N17 speeds huntingtin pile-up.

作者信息

Liebman Susan W, Meredith Stephen C

出版信息

Nat Chem Biol. 2010 Jan;6(1):7-8. doi: 10.1038/nchembio.279.

DOI:10.1038/nchembio.279

PMID:20016493

Abstract

摘要

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本文引用的文献

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J Mol Biol. 2009 May 22;388(5):919-27. doi: 10.1016/j.jmb.2009.01.032. Epub 2009 Jan 23.

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

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Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure.

J Mol Biol. 2007 Nov 30;374(3):688-704. doi: 10.1016/j.jmb.2007.09.023. Epub 2007 Sep 14.

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