长期禁欲后复吸寻求药物行为：环境刺激的作用
Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli.
作者信息
Fuchs R A, Lasseter H C, Ramirez D R, Xie X
机构信息
Department of Psychology, University of North Carolina, NC 27599-3270.
出版信息
Drug Discov Today Dis Models. 2008 Winter;5(4):251-258. doi: 10.1016/j.ddmod.2009.03.001.
Abstract
Successful treatment of drug addiction must involve relapse prevention informed by our understanding of the neurobiological bases of drug relapse. In humans, exposure to drug-associated environmental stimuli can elicit drug craving and relapse. Because exposure to drug-paired stimuli similarly induces drug-seeking behavior in laboratory animals, several animal models of drug relapse have been developed. Here, we review animal models of cue-induced drug relapse and critically evaluate their validity and utility in addressing human relapse behaviors.
摘要
成功治疗药物成瘾必须包含基于我们对药物复吸神经生物学基础的理解的预防复吸措施。在人类中，接触与药物相关的环境刺激会引发药物渴望和复吸。由于在实验动物中，接触与药物配对的刺激同样会诱导觅药行为，因此已经开发了几种药物复吸的动物模型。在这里，我们综述线索诱导的药物复吸动物模型，并严格评估它们在解决人类复吸行为方面的有效性和实用性。
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