Dubanova O P, Belavina I A, Tsymliakova L S, Fedoseeva O N
Klin Med (Mosk). 2009;87(10):50-5.
The aim of the study was to compare results of dopplerography characterizing hepatic and splenic blood flow at different stages of chronic viral hepatitis B and C and correlate them with histological findings and sclerosis. The study included 79 patients of whom 45 had chronic hepatitis B (CHB) and 34 hepatitis C (CHC). The most sensitive dopplerographic characteristics proved to be congestion index, liver vascular index, and hepatic hypertension index that started to change significantly at minimal activity of hepatitis and greatly deteriorated after development of liver cirrhosis. In both cases venous blood flow was affected more seriously than arterial one. Hepatic hyperperfusion progressed faster in CHC than in CHB. Dopplerographic characteristics correlated with histologic activity index, its components, and sclerosis index. Hence, the possibility of using dopplerographic studies for the evaluation of hepatic and splenic vasculature and indirect assessment of morphological changes in the liver.
该研究的目的是比较在慢性乙型和丙型病毒性肝炎不同阶段表征肝脾血流的多普勒超声检查结果,并将其与组织学发现和硬化情况相关联。该研究纳入了79例患者,其中45例患有慢性乙型肝炎(CHB),34例患有丙型肝炎(CHC)。最敏感的多普勒超声特征被证明是充血指数、肝脏血管指数和肝高血压指数,这些指标在肝炎活动度最小时就开始发生显著变化,在肝硬化形成后则严重恶化。在这两种情况下,静脉血流比动脉血流受到的影响更严重。CHC中肝血流灌注增加比CHB进展更快。多普勒超声特征与组织学活动指数、其组成部分以及硬化指数相关。因此,有可能利用多普勒超声检查来评估肝脾血管系统,并间接评估肝脏的形态学变化。