蛋白质对细胞及亚细胞pH值的适应性。
Adaptations of proteins to cellular and subcellular pH.
作者信息
Garcia-Moreno Bertrand
机构信息
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
J Biol. 2009;8(11):98. doi: 10.1186/jbiol199. Epub 2009 Dec 2.
Abstract
Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metric of charge distribution correlates better with subcellular pH than does pI. See research article http://www.biomedcentral.com/1741-7007/7/69.
摘要
基于生物信息学对蛋白质亚细胞定位与等电点（pI）或电荷分布之间相关性的搜索未能检测到有意义的相关性。发表在《BMC生物学》上的最新研究发现，电荷分布的一种物理化学指标与亚细胞pH的相关性比pI更好。见研究文章http://www.biomedcentral.com/1741-7007/7/69 。
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