Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA.
Cereb Cortex. 2010 Sep;20(9):2103-13. doi: 10.1093/cercor/bhp278. Epub 2009 Dec 17.
Major frontal lobe tracts and corpus callosum (CC) were investigated in 32 children with autism spectrum disorder (ASD, mean age: 5 years), 12 nonautistic developmentally impaired children (DI, mean age: 4.6 years), and 16 typically developing children (TD, mean age: 5.5 years) using diffusion tensor imaging tractography and tract-based spatial statistics. Various diffusion and geometric properties were calculated for uncinate fasciculus (UF), inferior fronto-occipital fasciculus (IFO), arcuate fasciculus (AF), cingulum (Cg), CC, and corticospinal tract. Fractional anisotropy was lower in the right UF, right Cg and CC in ASD and DI children; in right AF in ASD children; and in bilateral IFO in DI children, compared with TD children. Apparent diffusion coefficient was increased in right AF in both ASD and DI children. The ASD group showed shorter length of left UF and increased length, volume, and density of right UF; increased length and density of CC; and higher density of left Cg, compared with the TD group. Compared with DI group, ASD group had increased length, volume, and density of right UF; higher volume of left UF; and increased length of right AF and CC. Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features.
我们使用弥散张量成像纤维束追踪和基于纤维束的空间统计学方法，研究了 32 名自闭症谱系障碍（ASD）儿童（平均年龄：5 岁）、12 名非自闭症发育障碍（DI）儿童（平均年龄：4.6 岁）和 16 名典型发育儿童（TD）（平均年龄：5.5 岁）的主要额叶束和胼胝体（CC）。我们计算了钩束（UF）、下额枕束（IFO）、弓状束（AF）、扣带束（Cg）、CC 和皮质脊髓束的各种弥散和几何性质。与 TD 儿童相比，ASD 和 DI 儿童的右侧 UF、右侧 Cg 和 CC 的各向异性分数较低；ASD 儿童的右侧 AF 的各向异性分数较低；DI 儿童的双侧 IFO 的各向异性分数较低。ASD 和 DI 儿童的右侧 AF 的表观弥散系数增加。与 TD 组相比，ASD 组的左侧 UF 长度更短，右侧 UF 的长度、体积和密度增加；CC 的长度和密度增加；左侧 Cg 的密度更高。与 DI 组相比，ASD 组的右侧 UF 的长度、体积和密度增加；左侧 UF 的体积更大；右侧 AF 和 CC 的长度增加。双侧 UF 和右侧 AF 的体积以及左侧 UF 的纤维密度与自闭症特征呈正相关。
