Sivaswamy Lalitha, Kumar Ajay, Rajan Deepa, Behen Michael, Muzik Otto, Chugani Diane, Chugani Harry
Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.
J Child Neurol. 2010 Oct;25(10):1223-31. doi: 10.1177/0883073809358765. Epub 2010 Feb 22.
Children with autistic spectrum disorder are known to have histopathological abnormalities in the cerebellum. Diffusion tensor imaging has been utilized to study abnormalities in connectivity and microintegrity in brains of such children. A region of interest approach was adopted to study cerebellar outflow and inflow pathways in 27 children (24 males; mean age, 5.0 years) with autism, and comparison was made with 16 normally developing controls. An increase in the mean diffusivity of bilateral superior cerebellar peduncles in those with autistic spectrum disorder was noted, as was a reversal of the asymmetry pattern in fractional anisotropy of the middle cerebellar peduncle and the inferior cerebellar peduncle in the autistic spectrum disorder group, compared with controls. This study reiterates the underconnectivity between the cerebellum and neocortex, using diffusion tensor imaging.
已知患有自闭症谱系障碍的儿童小脑存在组织病理学异常。弥散张量成像已被用于研究这类儿童大脑中的连接性和微完整性异常。采用感兴趣区域方法研究了27名自闭症儿童（24名男性；平均年龄5.0岁）的小脑流出和流入通路，并与16名正常发育的对照组进行了比较。结果发现，自闭症谱系障碍患儿双侧上小脑脚的平均扩散率增加，与对照组相比，自闭症谱系障碍组中小脑脚和下小脑脚的各向异性分数不对称模式也发生了反转。本研究利用弥散张量成像再次证实了小脑与新皮质之间连接不足的情况。
