Ettinger E R, Wyatt H J, London R
State University of New York, State College of Optometry, NY 10010.
Invest Ophthalmol Vis Sci. 1991 Mar;32(3):501-9.
Variations in anisocoria in light and dark conditions are used to help diagnose normal and pathologic conditions; however, there have been few observations of anisocoria in different lighting and accommodative conditions. The authors measured pupil size photographically in a group of normal subjects examined in six conditions that were controlled for illumination and accommodation. Greater variation and average extent of anisocoria were found in conditions that resulted in larger pupil size. A subset of subjects repeated several sessions. For this group, the average value of anisocoria and variability tended to be greater in dark conditions. These results show that the observation of anisocoria varies under different conditions, and they suggest careful consideration of conditions used clinically to assess pupil equality. Our analysis shows that for a given observation threshold, conditions that produce even modest changes in variability can cause dramatic changes in the probability of observing anisocoria.
通过观察明、暗条件下的瞳孔不等大变化，有助于诊断正常和病理状态；然而，对于不同光照和调节条件下的瞳孔不等大情况，相关观察较少。作者对一组正常受试者在六种控制了照明和调节的条件下进行了瞳孔大小的摄影测量。在导致瞳孔较大的条件下，发现瞳孔不等大的变化更大且平均程度更高。一部分受试者重复了多个测试环节。对于这组受试者，在黑暗条件下，瞳孔不等大的平均值和变异性往往更大。这些结果表明，瞳孔不等大的观察结果在不同条件下存在差异，这提示在临床评估瞳孔是否等大时，需谨慎考虑所采用的条件。我们的分析表明，对于给定的观察阈值，即使变异性出现适度变化的条件，也可能导致观察到瞳孔不等大的概率发生显著变化。
