评论：NTP研究动物模型的最新进展
Commentary: update on animal models for NTP studies.
作者信息
King-Herbert Angela P, Sills Robert C, Bucher John R
机构信息
Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC 27709, USA.
出版信息
Toxicol Pathol. 2010 Jan;38(1):180-1. doi: 10.1177/0192623309356450. Epub 2009 Dec 17.
Based on recommendations of participants at the National Toxicology Program (NTP) workshop "Animal Models for the NTP Cancer Bioassay: Strains and Stocks-Should We Switch?" some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies.
根据国家毒理学计划（NTP）研讨会“NTP癌症生物测定的动物模型：品系和种群——我们应该更换吗？”参与者的建议，对NTP啮齿动物癌症生物测定进行了一些修改。B6C3F1仍然是癌症生物测定中使用的小鼠模型。将通过NTP内的一个新分支——宿主易感性分支来探索使用多种品系的小鼠。对几种大鼠模型进行了评估；Harlan Sprague Dawley大鼠目前正在NTP研究中使用。
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