Department of Sports Sciences, Japan Institute of Sports Sciences, Tokyo, Japan.
Med Sci Sports Exerc. 2010 Jul;42(7):1279-85. doi: 10.1249/MSS.0b013e3181ce61a5.
Several recent studies have shown that resistance exercise combined with vascular occlusion effectively causes increases in muscular size and strength. Researchers speculated that the vascular occlusion-induced local hypoxia may contribute to the adaptations via promoting anabolic hormone secretions stimulated by local accumulation of metabolic subproducts. Here, we examined whether acute systemic hypoxia affects metabolic and hormonal responses to resistance exercise.
Twelve male subjects participated in two experimental trials: 1) resistance exercise while breathing normoxic air [normoxic resistance exercise (NR)] and 2) resistance exercise while breathing 13% oxygen [hypoxic resistance exercise (HR)]. The resistance exercises (bench press and leg press) consisted of 10 repetitions for five sets at 70% of maximum strength with 1-min rest between sets. Blood lactate, serum growth hormone (GH), epinephrine (E), norepinephrine (NE), insulin-like growth factor 1, testosterone, and cortisol concentrations were measured before normoxia and hypoxia exposures, 15 min after the exposures, and at 0, 15, 30, and 60 min after the exercises.
Lactate significantly increased after exercises in both trials (P < 0.05). In the HR trial, GH and cortisol significantly increased after the exercise (P < 0.05) but not in the NR trial. The E, NE, insulin-like growth factor 1, and testosterone significantly increased after the exercises in both trials (P < 0.05). The mean values of lactate, GH, E, and NE after exercises were significantly higher in the HR trial than those in the NR trial (P < 0.05).
These findings suggest that resistance exercise in hypoxic condition caused greater accumulation of metabolites and strong anabolic hormone response.
最近的几项研究表明，抗阻运动结合血管闭塞能有效地增加肌肉的大小和力量。研究人员推测，血管闭塞引起的局部缺氧可能通过促进代谢副产物局部积累刺激的合成代谢激素分泌来促进适应。在这里，我们研究了急性全身缺氧是否会影响抗阻运动的代谢和激素反应。
12 名男性受试者参加了两项实验：1）在呼吸常氧空气的情况下进行抗阻运动[常氧抗阻运动（NR）]和 2）在呼吸 13%氧气的情况下进行抗阻运动[缺氧抗阻运动（HR）]。抗阻运动（卧推和腿推）包括 10 次重复，共 5 组，强度为最大力量的 70%，每组之间休息 1 分钟。在常氧和缺氧暴露前、暴露后 15 分钟以及运动后 0、15、30 和 60 分钟测量血乳酸、血清生长激素（GH）、肾上腺素（E）、去甲肾上腺素（NE）、胰岛素样生长因子 1、睾酮和皮质醇浓度。
两种试验中运动后乳酸均显著升高（P<0.05）。在 HR 试验中，运动后 GH 和皮质醇显著升高（P<0.05），而 NR 试验中则没有。两种试验中，运动后 E、NE、胰岛素样生长因子 1 和睾酮均显著升高（P<0.05）。HR 试验中运动后乳酸、GH、E 和 NE 的平均值明显高于 NR 试验（P<0.05）。
这些发现表明，在缺氧条件下进行抗阻运动可导致代谢产物的积累增加和较强的合成代谢激素反应。
