Svatek Robert S, Siefker-Radtke Arlene, Dinney Colin P
The University of Texas MD Anderson Cancer Center, Department of Urologic Oncology;
Can Urol Assoc J. 2009 Dec;3(6 Suppl 4):S228-31. doi: 10.5489/cuaj.1203.
Metastatic or unresectable disease is identified in approximately 20% of patients presenting with invasive urothelial cancer. In addition, up to 50% of patients will develop metastases following radical cystectomy for clinically localized disease. Multiagent cisplatin-based chemotherapy is considered standard first-line treatment for these patients. Although urothelial cancer is considered a chemosensitive tumour, metastatic disease is associated with poor prognosis and short-term survival. Here, we review the role of a multidisciplinary approach to treating patients with metastatic urothelial cancer.
在出现浸润性尿路上皮癌的患者中,约20%被诊断为转移性或不可切除性疾病。此外,高达50%的临床局限性疾病患者在根治性膀胱切除术后会发生转移。基于顺铂的多药化疗被认为是这些患者的标准一线治疗方法。尽管尿路上皮癌被认为是一种对化疗敏感的肿瘤,但转移性疾病的预后较差且短期生存率低。在此,我们综述多学科方法在治疗转移性尿路上皮癌患者中的作用。