橙皮苷对尼古丁毒性的影响及组织病理学研究。

Effect of hesperidin on nicotine toxicity and histopathological studies.

机构信息

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002, India.

出版信息

Toxicol Mech Methods. 2007;17(4):233-9. doi: 10.1080/15376510600970430.

PMID:20020973

Abstract

ABSTRACT The study was designed to evaluate the protective nature of the bioflavonoid hesperidin on nicotine-induced toxicity in male Wistar rats. Lung toxicity was induced by subcutaneous injection of nicotine at a dose of 2.5 mg/kg of body weight (5 days a week for 22 weeks). The nicotine-treated rats showed a significant increase in the marker enzymes, cholesterol, triglycerides, phospholipids, and free fatty acids. There was a significant protection on hesperidin administration at a dose of 25 mg/kg body weight in nicotine-treated rats. This finding is supported by histopathological studies of liver, lung, and kidney. The results of the present study suggest that hesperidin showed protective effects against nicotine-induced toxicity.

摘要

摘要本研究旨在评估类黄酮橙皮苷对尼古丁诱导的雄性 Wistar 大鼠毒性的保护作用。通过皮下注射尼古丁（每周 5 天，共 22 周，剂量为 2.5mg/kg 体重）诱导肺毒性。尼古丁处理的大鼠标记酶、胆固醇、甘油三酯、磷脂和游离脂肪酸显著增加。给予 25mg/kg 体重的橙皮苷可显著减轻尼古丁处理大鼠的毒性。这一发现得到了肝、肺和肾组织病理学研究的支持。本研究结果表明，橙皮苷对尼古丁诱导的毒性具有保护作用。