Department of Pharmaceutical Sciences, University of Calabria, Ed. Polifunzionale, Rende, Italy.
J Drug Target. 2010 Jun;18(5):404-11. doi: 10.3109/10611860903494211.
In this study, we report the results of our investigations on the percutaneous permeation profiles of Diclofenac sodium, Paracetamol, Propanolol hydrochloride, and alpha-Tocopherol from the different lyotropic liquid crystalline phases obtained by Pluronic P105/water mixtures, in order to understand if the particular assembly shown in the formulations could influence the delivery across the skin. Recent studies have focused on the Pluronic liquid crystalline phases to evaluate the potential use of these phases in drug delivery, but no comparative investigation has been yet performed on the drug permeation from the different liquid crystalline phases obtained by the same Pluronic surfactant. The cubic, hexagonal, and lamellar mesophases (loading the above-mentioned drug) were characterized by Deuterium Nuclear Magnetic Resonance spectroscopy and Polarized Optical Microscopy observations. Results revealed that the liquid crystalline gel microscopic structure obtained in the different formulations drastically affects the drug percutaneous availability. As a consequence these systems could be proposed as novel transdermal drug delivery systems.
在这项研究中，我们报告了我们对不同溶致液晶相的经皮渗透曲线的研究结果，这些液晶相是由泊洛沙姆 P105/水混合物获得的，目的是了解制剂中显示的特定组装是否会影响药物透过皮肤的传递。最近的研究集中在泊洛沙姆液晶相上，以评估这些相在药物传递中的潜在用途，但尚未对同一泊洛沙姆表面活性剂获得的不同液晶相的药物渗透进行比较研究。立方相、六方相和层状相（负载上述药物）通过氘核磁共振光谱和偏光显微镜观察进行了表征。结果表明，不同配方中获得的液晶凝胶微观结构极大地影响了药物的经皮可用性。因此，这些系统可以作为新型的透皮药物传递系统。
