Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany.
Acta Obstet Gynecol Scand. 2010;89(1):7-14. doi: 10.3109/00016340903322727.
To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting.
In a standardized, questionnaire-based interview, women selected from a control cohort for association studies were asked retrospectively about nausea and vomiting during their first pregnancy.
A total of 593 women who had completed at least one pregnancy and for whom germline DNA was available were selected.
Eight SNPs in the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, and NK1R (TACR1) were tested using polymerase chain reaction. The occurrence of nausea and vomiting was correlated with the patients' genotyping results and medical history parameters.
Both young age at first pregnancy and positive smoking status were significantly associated with vomiting and nausea during pregnancy. After adjustment for these two parameters, the two SNPs rs6806362 (odds ratio (OR) 1.38 per allele; 95% confidence interval (CI) 1.06-1.79; p = 0.017) and rs6807670 (OR 1.37; 95% CI 1.05-1.79 per allele; p = 0.023) were marginally associated with pregnancy-related nausea. None of the other polymorphisms showed any association.
Polymorphisms in the subunit gene HTR3C of the serotonin receptor may be involved in the pathogenesis of pregnancy-associated nausea.
评估与已知参与恶心和呕吐发病机制的基因相关的妊娠相关症状与常见单核苷酸多态性（SNP）之间的关联。
在基于标准化问卷的回顾性访谈中，从关联研究的对照队列中选择的女性被问及她们第一次妊娠期间的恶心和呕吐情况。
共选择了 593 名至少完成一次妊娠且有胚系 DNA 的女性。
使用聚合酶链反应检测 5-羟色胺受体基因 HTR3A、HTR3B、HTR3C、HTR3D、HTR3E 和 NK1R（TACR1）中的 8 个 SNP。将恶心和呕吐的发生与患者的基因分型结果和病史参数相关联。
首次妊娠年龄较小和吸烟状况阳性均与妊娠期间呕吐和恶心显著相关。在调整这两个参数后，两个 SNP rs6806362（每个等位基因的优势比（OR）为 1.38；95%置信区间（CI）为 1.06-1.79；p=0.017）和 rs6807670（OR 每个等位基因 1.37；95%CI 为 1.05-1.79；p=0.023）与妊娠相关的恶心相关，呈边缘相关。其他多态性均无相关性。
5-羟色胺受体亚基基因 HTR3C 的多态性可能与妊娠相关的恶心发病机制有关。
