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伽玛刀放射外科治疗前庭神经鞘瘤:病例报告及文献复习。

Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature.

机构信息

Gamma Knife of Spokane, 910 W 5th Ave, Suite 102, Spokane, WA 99204, USA.

出版信息

World J Surg Oncol. 2009 Dec 18;7:100. doi: 10.1186/1477-7819-7-100.

DOI:10.1186/1477-7819-7-100
PMID:20021676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2803477/
Abstract

Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve. Patients with these tumours almost always present with signs of hearing loss, and many also experience tinnitus, vertigo, and equilibrium problems. Following diagnosis with contrast enhanced MRI, patients may choose to observe the tumour with subsequent scans or seek active treatment in the form of microsurgery, radiosurgery, or radiotherapy. Unfortunately, definitive guidelines for treating vestibular schwannomas are lacking, because of insufficient evidence comparing the outcomes of therapeutic modalities.We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit. Audible clicking is a symptom that, to our knowledge, has not been associated with vestibular schwannoma in the literature. We discuss the diagnosis and patient's decision-making process, which led to treatment with Gamma Knife radiosurgery. Treatment resulted in an excellent radiographic response and complete hearing preservation. This case highlights an atypical presentation of vestibular schwannoma, associated with audible "clicks" and normal hearing. We also provide a concise review of the available literature on modern vestibular schwannoma treatment, which may be useful in guiding treatment decisions.

摘要

前庭神经鞘瘤,也称为听神经瘤,是前庭耳蜗神经的良性肿瘤。这些肿瘤的患者几乎总是表现出听力损失的迹象,许多患者还会出现耳鸣、眩晕和平衡问题。在进行对比增强 MRI 诊断后,患者可能会选择通过后续扫描观察肿瘤,或选择接受显微手术、放射外科或放疗等积极治疗。不幸的是,由于缺乏比较治疗方式结果的充分证据,因此缺乏治疗前庭神经鞘瘤的明确指南。我们报告了一个当代病例,描述了一位患者因头晕和耳部“咔嗒”声就诊,而无听力损失,发现前庭神经鞘瘤的情况。可闻性咔嗒声是一种症状,据我们所知,在文献中尚未与前庭神经鞘瘤相关。我们讨论了诊断和患者的决策过程,最终选择接受伽玛刀放射外科治疗。治疗后获得了极好的影像学反应和完全的听力保留。该病例突出了前庭神经鞘瘤的一种非典型表现,伴有可闻性“咔嗒”声和正常听力。我们还对现代前庭神经鞘瘤治疗的现有文献进行了简洁的回顾,这可能有助于指导治疗决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b2/2803477/1ab7095ca59a/1477-7819-7-100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b2/2803477/7b8c62ef1cbe/1477-7819-7-100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b2/2803477/1ab7095ca59a/1477-7819-7-100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b2/2803477/7b8c62ef1cbe/1477-7819-7-100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b2/2803477/1ab7095ca59a/1477-7819-7-100-2.jpg

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本文引用的文献

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Vestibular schwannoma: surgery or gamma knife radiosurgery? A prospective, nonrandomized study.前庭神经鞘瘤:手术还是伽玛刀放射外科治疗?一项前瞻性、非随机研究。
Neurosurgery. 2009 Apr;64(4):654-61; discussion 661-3. doi: 10.1227/01.NEU.0000340684.60443.55.
2
Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?前庭神经鞘瘤立体定向放射外科手术中的听力保留:真正重要的是什么?
J Neurosurg. 2008 Dec;109 Suppl:129-36. doi: 10.3171/JNS/2008/109/12/S20.
3
Conservative management of vestibular schwannomas: third review of a 10-year prospective study.
前庭神经鞘瘤的保守治疗:一项10年前瞻性研究的第三次综述
Clin Otolaryngol. 2008 Jun;33(3):255-9. doi: 10.1111/j.1749-4486.2008.01705.x.
4
Treatment of vestibular schwannomas. Why, when and how?前庭神经鞘瘤的治疗。为何、何时以及如何治疗?
Acta Neurochir (Wien). 2007;149(7):647-60; discussion 660. doi: 10.1007/s00701-007-1179-0. Epub 2007 Jun 11.
5
Stereotactic radiation techniques in the treatment of acoustic schwannomas.立体定向放射技术在听神经瘤治疗中的应用
Otolaryngol Clin North Am. 2007 Jun;40(3):571-88, ix. doi: 10.1016/j.otc.2007.04.001.
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Comparison of growth patterns of acoustic neuromas with and without radiosurgery.接受和未接受放射外科治疗的听神经瘤生长模式比较。
Otol Neurotol. 2006 Aug;27(5):705-12. doi: 10.1097/01.mao.0000226302.59198.87.
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Patient outcomes after vestibular schwannoma management: a prospective comparison of microsurgical resection and stereotactic radiosurgery.前庭神经鞘瘤治疗后的患者预后:显微手术切除与立体定向放射外科的前瞻性比较。
Neurosurgery. 2006 Jul;59(1):77-85; discussion 77-85. doi: 10.1227/01.NEU.0000219217.14930.14.
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Descriptive epidemiology of vestibular schwannomas.前庭神经鞘瘤的描述性流行病学
Neuro Oncol. 2006 Jan;8(1):1-11. doi: 10.1215/S1522851704001097.
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Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma.前庭神经鞘瘤伽玛刀立体定向放射外科治疗后的听力保留
Cancer. 2005 Aug 1;104(3):580-90. doi: 10.1002/cncr.21190.
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Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm.听神经瘤的保守治疗:一项荟萃分析及建议的治疗算法。
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