[CD147、基质金属蛋白酶及转化生长因子β1在乳腺癌中的表达]

[Expression of CD147, matrix metalloproteinases and transforming growth factor beta1 in breast cancer].

作者信息

Xue Song, Li Shou-xin, Wu Zheng-sheng, Wang Xiao-nan, Wu Qiang, Yang Feng

机构信息

Department of Pathology, Anhui Medical University, Hefei 230032, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2009 Aug;38(8):524-8.

PMID:20021962

Abstract

OBJECTIVE

To investigate the expression of CD147, matrix metalloproteinase (MMP)-2, MMP-9, Transforming growth factor (TGFbeta1) and TGFbetaRI proteins and their relationships to breast cancer.

METHODS

The expression of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins was examined on tissue chips containing 160 cases of breast carcinomas by S-P immunohistochemical method.

RESULTS

The positive rates of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins were 87.5% (140/160), 96.9% (155/160), 95.0% (152/160), 73.7% (118/160) and 60.6% (97/160), respectively. The expression of CD147 was positively correlated with axillary lymph node metastasis, TNM staging and HER2 over expression (P < 0.01, P < 0.05 and P < 0.01, respectively), and inversely correlated with PR expression (P < 0.05). The patients' relapse-free survival was shorter in TGFbeta1-positive group than in TGFbeta1 negative group (P < 0.05). Both the expression of MMP-2 and MMP-9 were positively correlated with CD147 expression; and both the expression of TGFbeta1 and TGFbetaRI were positively correlated with CD147 expression (P < 0.01 and P < 0.05, respectively).

CONCLUSION

The expression of CD147 is considered closely correlated with tumor invasion, metastasis and prognosis in breast cancer, and has also a close correlation with MMP-2, MMP-9, TGFbeta1 and TGFbetaRI expression.

摘要

目的

研究CD147、基质金属蛋白酶（MMP）-2、MMP-9、转化生长因子（TGFβ1）和TGFβRI蛋白的表达及其与乳腺癌的关系。

方法

采用S-P免疫组织化学方法检测160例乳腺癌组织芯片中CD147、MMP-2、MMP-9、TGFβ1和TGFβRI蛋白的表达。

结果

CD147、MMP-2、MMP-9、TGFβ1和TGFβRI蛋白的阳性率分别为87.5%（140/160）、96.9%（155/160）、95.0%（152/160）、73.7%（118/160）和60.6%（97/160）。CD147的表达与腋窝淋巴结转移、TNM分期及HER2过表达呈正相关（分别为P<0.01、P<0.05和P<0.01），与PR表达呈负相关（P<0.05）。TGFβ1阳性组患者的无复发生存期短于TGFβ1阴性组（P<0.05）。MMP-2和MMP-9的表达均与CD147表达呈正相关；TGFβ1和TGFβRI的表达均与CD147表达呈正相关（分别为P<0.01和P<0.05）。