Lenković Maja, Cabrijan Leo, Gruber Franjo, Batinac Tanja, Manestar-Blazić Teo, Stanić Zgombić Zrinka, Stasić Adalbert
University Department of Dermatology and Venereology, Rijeka University Hospital Center, Kresimirova 42, HR-51000 Rijeka, Croatia.
Acta Dermatovenerol Croat. 2009;17(4):263-7.
The aim of this study was to investigate the contribution of progesterone in the development of primary varicose veins on lower limbs during pregnancy. In 50 primiparae with varicose veins, serum progesterone level was quantitatively determined in the 14th week of pregnancy and results were compared with those obtained in a control group of 25 primiparae without visible varicose veins. The mean serum progesterone concentration recorded in pregnant women with dilated veins (159.9+/-15.8 nmol/L) was significantly higher as compared with the control group (159.9+/-15.8 nmol/L vs. 40.4+/-1.6 nmol/L; P<0.0001). These findings supported the role of hormonal factor in the development of varicose veins in women.
本研究旨在探讨孕期孕酮在下肢原发性静脉曲张形成过程中的作用。选取50例患有静脉曲张的初产妇，于妊娠第14周定量测定血清孕酮水平，并将结果与25例无明显静脉曲张的初产妇对照组进行比较。有静脉曲张的孕妇记录的平均血清孕酮浓度（159.9±15.8 nmol/L）显著高于对照组（159.9±15.8 nmol/L对40.4±1.6 nmol/L；P<0.0001）。这些发现支持了激素因素在女性静脉曲张形成中的作用。
