Derache R
Ann Nutr Aliment. 1976;30(5-6):823-9.
Once the pair nitrate-nitrite--in quantity respectively set by the ingestion level or transformation level by intestinal bacteria--has entered through the intestinal mucosa, it may react with active biochemical groups. Nitrite, owing to its high oxido-reduction potential, may induce the oxidation of a large number of compounds, as for example the Fe++ heme-Fe+++ hemine system, reduced cytochromes-oxidized cytochromes system, etc. If the presence of nitrite in blood is not clearly established, this is due to the nitrite high chemical reactivity. Moreover, a transformation by the tissues of nitrates into nitrites after a nitro-reduction is quite possible.
一旦由摄入水平或肠道细菌转化水平分别设定的硝酸盐-亚硝酸盐对通过肠黏膜进入体内，它可能会与活性生化基团发生反应。由于亚硝酸盐具有较高的氧化还原电位，它可能会诱导大量化合物的氧化，例如亚铁血红素-高铁血红素系统、还原型细胞色素-氧化型细胞色素系统等。如果血液中亚硝酸盐的存在不明确，这是由于亚硝酸盐具有很高的化学反应活性。此外，硝酸盐经硝基还原后被组织转化为亚硝酸盐是很有可能的。
