Bannister B, Corbel M J
Infectious Diseases Department, Royal Free Hospital Infectious Diseases Unit, Coppetts Wood Hospital, Muswell Hill, London, U.K.
J Infect. 1991 Jan;22(1):11-5. doi: 10.1016/0163-4453(91)90814-9.
Twenty-nine healthy persons were Schick tested as part of their occupational health examination. All but three of them had been previously immunised against diphtheria. One unimmunised person had a history of diphtheria. Blood samples were taken before and at varied intervals after the Schick tests in order to determine whether the Schick test antigen was immunogenic. Of the 29 persons tested, 21 were Schick-negative, three were Schick-positive. Four pseudoreactors were Schick-negative, one pseudoreactor was Schick-positive. Only four of the 29 had any significant rise in antitoxin titre after Schick testing. Three of these were Schick-negative, while one was a pseudoreactor who was negative at a later reading. We conclude that Schick testing is not reliably immunogenic and that, contrary to expectation, it cannot be assumed to elicit a useful booster response in previously immunised persons.
29名健康人作为职业健康检查的一部分接受了锡克试验。除3人外，其余所有人此前都接种过白喉疫苗。1名未接种疫苗的人有白喉病史。在锡克试验之前和之后的不同时间间隔采集血样，以确定锡克试验抗原是否具有免疫原性。在接受测试的29人中，21人锡克试验呈阴性，3人呈阳性。4名假反应者锡克试验呈阴性，1名假反应者呈阳性。29人中只有4人在锡克试验后抗毒素滴度有显著升高。其中3人锡克试验呈阴性，1人是假反应者，后期检测呈阴性。我们得出结论，锡克试验并非可靠地具有免疫原性，而且与预期相反，不能假定它会在先前接种过疫苗的人中引发有效的加强反应。
