白藜芦醇 4'-酯类似物的合成及其在恶性黑色素瘤和胰腺细胞系中的评价。
Synthesis of 4'-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines.
机构信息
Department of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
出版信息
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1198-201. doi: 10.1016/j.bmcl.2009.12.006. Epub 2009 Dec 5.
PMID:20022501
Abstract
4'-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4'-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells.
摘要
合成了疾病预防剂白藜芦醇的 4'-酯类似物，并评估了它们作为抗黑色素瘤和胰腺癌药物的潜力。采用脱羰 Heck 偶联反应构建了保护的二苯乙烯核心结构。4'-乙酸酯和棕榈酸酯类似物在 DM443 和 DM738 细胞中表现出对正常 NHDF 细胞的选择性活性。
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