Department of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1198-201. doi: 10.1016/j.bmcl.2009.12.006. Epub 2009 Dec 5.
4'-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4'-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells.
合成了疾病预防剂白藜芦醇的 4'-酯类似物，并评估了它们作为抗黑色素瘤和胰腺癌药物的潜力。采用脱羰 Heck 偶联反应构建了保护的二苯乙烯核心结构。4'-乙酸酯和棕榈酸酯类似物在 DM443 和 DM738 细胞中表现出对正常 NHDF 细胞的选择性活性。
