Finzi E, Harkins R, Horn T
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
J Invest Dermatol. 1991 Mar;96(3):328-32. doi: 10.1111/1523-1747.ep12465223.
Transforming growth factor-alpha (TGF-alpha) is a potent mitogen for epithelial cells that is expressed at low levels in normal epidermis and overexpressed in psoriasis. Epidermal growth factor (EGF) has been shown to inhibit hair growth but stimulate the growth of sebaceous and sweat glands, suggesting a potential role for a member of the EGF/TGF-alpha family in the normal development and function of skin appendages as well as epidermis. The present work demonstrates TGF-alpha protein in eccrine ducts, and eccrine, sebaceous, and apocrine glands. The proliferative dermal hair bulb does not express TGF-alpha in contrast to the differentiated outer root sheath hair follicle epithelia. In addition, hyperproliferative skin diseases including bullous congenital ichthyosiform erythroderma, squamous cell carcinoma, and psoriasis show increased TGF-alpha expression. Thus, TGF-alpha may play a role in the morphogenesis and function of normal skin appendages and its overexpression is common in benign and malignant hyperproliferative skin diseases.
转化生长因子-α（TGF-α）是一种对上皮细胞有强大作用的促有丝分裂原，在正常表皮中低水平表达，而在银屑病中过度表达。表皮生长因子（EGF）已被证明可抑制毛发生长，但能刺激皮脂腺和汗腺的生长，这表明EGF/TGF-α家族成员在皮肤附属器以及表皮的正常发育和功能中可能发挥作用。目前的研究表明，TGF-α蛋白存在于小汗腺导管、小汗腺、皮脂腺和大汗腺中。与分化的外根鞘毛囊上皮不同，增殖性真皮毛球不表达TGF-α。此外，包括大疱性先天性鱼鳞病样红皮病、鳞状细胞癌和银屑病在内的增殖性皮肤病显示TGF-α表达增加。因此，TGF-α可能在正常皮肤附属器的形态发生和功能中发挥作用，其过度表达在良性和恶性增殖性皮肤病中很常见。
