妊娠期及产后至少 6 个月内早发型 HELLP 综合征与早发型子痫前期的临床差异。

Clinical differences between early-onset HELLP syndrome and early-onset preeclampsia during pregnancy and at least 6 months postpartum.

机构信息

Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.

出版信息

Am J Obstet Gynecol. 2010 Mar;202(3):271.e1-5. doi: 10.1016/j.ajog.2009.10.874. Epub 2009 Dec 22.

DOI:10.1016/j.ajog.2009.10.874

PMID:20022586

Abstract

OBJECTIVE

We sought to evaluate whether clinical and laboratory variables differ between former patients who had HELLP syndrome and former patients who had preeclampsia (PE) without HELLP.

STUDY DESIGN

We compared early-onset HELLP (n = 75) with early-onset PE (n = 40) with respect to clinical features during the hypertensive complication and to metabolic, hemodynamic, and hemostatic variables determined at least 6 months postpartum.

RESULTS

HELLP differed from PE by a borderline higher frequency of eclampsia (13% vs 3%) during the complication, and by a lower prevalence of hypertension (19% vs 33%), proteinuria (2% vs 23%), thrombophilia (6% vs 27%), obesity (9% vs 33%), hypertriglyceridemia (1% vs 15%), hyperglycemia (0% vs 11%), and elevated levels of fasting homocysteine (6% vs 21%) at least 6 months postpartum.

CONCLUSION

Women with HELLP had fewer signs of abnormalities consistent with the metabolic syndrome and a 4-fold lower prevalence of thrombophilia as compared with PE women without HELLP.

摘要

目的

我们旨在评估有 HELLP 综合征的前患者与无 HELLP 的子痫前期（PE）前患者之间的临床和实验室变量是否存在差异。

研究设计

我们比较了早发型 HELLP（n=75）与早发型 PE（n=40）在高血压并发症期间的临床特征，以及至少产后 6 个月时确定的代谢、血液动力学和止血变量。

结果

HELLP 在并发症期间子痫（13% vs 3%）的发生率略高，高血压（19% vs 33%）、蛋白尿（2% vs 23%）、血栓形成倾向（6% vs 27%）、肥胖（9% vs 33%）、高三酰甘油血症（1% vs 15%）、高血糖（0% vs 11%）和空腹同型半胱氨酸水平升高（6% vs 21%）的发生率较低。