Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Int J Gynaecol Obstet. 2010 Apr;109(1):49-51. doi: 10.1016/j.ijgo.2009.11.004. Epub 2009 Dec 22.
To determine whether injecting the colpotomy wound with diluted vasopressin decreases vaginal bleeding after laparoscopically assisted vaginal hysterectomy (LAVH).
In this prospective controlled study 100 patients who underwent LAVH from July 1, 2005 to June 30, 2007, were randomized to receive an injection of vasopressin (n=50) or normal saline (n=50) solution in the colpotomy wound.
In the vasopressin group, bleeding from the colpotomy wound occurred for more than 7 days in 9 patients (18%), and none was bleeding after 1 month; in the control group, the corresponding values were 29 (58%) and 2 (4%). Compared with the study group, the control group had a significantly higher rate of chronic bleeding from the colpotomy wound for more than 7 days and for more than 14 days after LAVH (P<0.001 for both).
Infiltrating the colpotomy wound with diluted vasopressin was found to prevent chronic vaginal bleeding, which frequently occurs following LAVH.
确定在腹腔镜辅助阴道子宫切除术（LAVH）后向阴道切开处注射稀释的血管加压素是否能减少阴道出血。
在这项前瞻性对照研究中，2005 年 7 月 1 日至 2007 年 6 月 30 日期间，有 100 名接受 LAVH 的患者被随机分为两组，一组在阴道切开处注射血管加压素（n=50），另一组注射生理盐水（n=50）溶液。
在血管加压素组，有 9 名患者（18%）的阴道切开处出血超过 7 天，且无一人在 1 个月后出血；而在对照组，相应的数值分别为 29 名（58%）和 2 名（4%）。与研究组相比，对照组在 LAVH 后超过 7 天和超过 14 天的慢性阴道切开处出血的发生率明显更高（两者均 P<0.001）。
向阴道切开处注射稀释的血管加压素可以预防 LAVH 后经常发生的慢性阴道出血。
