Autry Andrew R, Trevathan Edwin, Van Naarden Braun Kim, Yeargin-Allsopp Marshalyn
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Child Neurol. 2010 Apr;25(4):441-7. doi: 10.1177/0883073809348355. Epub 2009 Dec 18.
The magnitude and causes of death among a cohort of children with epilepsy were determined. A follow-up study with a population-based cohort of 10-year-old children in the metropolitan Atlanta area with epilepsy was conducted. The National Death Index and linkage to State of Georgia death certificates were used to identify deaths. The authors estimated the expected numbers of deaths by applying mortality rates adjusted by age, race, and sex for the entire state of Georgia to the population for the follow-up period. Among the 688 children who were in the final epilepsy cohort, 64 deaths occurred; 20.6 deaths were expected (mortality ratio adjusted for age, race, and sex = 3.11). The mortality ratios for children with Lennox-Gastaut syndrome and infantile spasms were 13.92 and 11.91, respectively. Children and adolescents with epilepsy, especially those with Lennox-Gastaut syndrome or infantile spasms, have an increased risk of death.
确定了一组癫痫患儿的死亡规模及原因。对大亚特兰大地区10岁癫痫患儿的人群队列进行了一项随访研究。利用国家死亡指数并与佐治亚州死亡证明建立联系来确定死亡情况。作者通过将佐治亚州全州按年龄、种族和性别调整的死亡率应用于随访期间的人群来估计预期死亡人数。在最终癫痫队列中的688名儿童中，发生了64例死亡；预期死亡20.6例（经年龄、种族和性别调整的死亡率比 = 3.11）。Lennox-Gastaut综合征和婴儿痉挛症患儿的死亡率比分别为13.92和11.91。患有癫痫的儿童和青少年，尤其是患有Lennox-Gastaut综合征或婴儿痉挛症的儿童和青少年，死亡风险增加。
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