植物 SUN 结构域蛋白：假定的植物 LINC 复合物的组成部分？
Plant SUN domain proteins: components of putative plant LINC complexes?
机构信息
School of Life Sciences, Oxford Brookes University, Oxford, UK.
出版信息
Plant Signal Behav. 2010 Feb;5(2):154-6. doi: 10.4161/psb.5.2.10458. Epub 2010 Feb 27.
Abstract
We have recently reported the identification and characterization of Sad1/UNC84 (SUN) domain proteins in various plant species. In animals and yeasts, SUN domain proteins are localized at the inner nuclear membrane and form a bridge across the nuclear envelope (NE) by interacting with outer nuclear membrane-localized Klarsicht/Anc-1/Syne-1 homology (KASH) domain proteins. This bridge physically connects cytoskeletal elements with chromatin and nucleoskeletal components. These multiprotein complexes are essential for various cellular and nuclear processes. The identification of SUN domain proteins provides the first evidence of putative NE bridging complexes in plants. Here we speculate on the composition and functions of these in regards to our current understanding of plant SUN domain proteins.
摘要
我们最近在各种植物物种中鉴定和描述了 Sad1/UNC84（SUN）结构域蛋白。在动物和酵母中，SUN 结构域蛋白定位于核内膜，并通过与定位于外核膜的 Klarsicht/Anc-1/Syne-1 同源（KASH）结构域蛋白相互作用形成横跨核膜（NE）的桥梁。这座桥梁将细胞骨架元件与染色质和核骨架成分物理连接起来。这些多蛋白复合物对于各种细胞和核过程至关重要。SUN 结构域蛋白的鉴定为植物中潜在的核膜桥接复合物提供了第一个证据。在这里，我们根据我们目前对植物 SUN 结构域蛋白的理解，推测这些复合物的组成和功能。
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