Department of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) and Paris 12 University, Créteil, France.
Bone Marrow Transplant. 2010 Sep;45(9):1423-6. doi: 10.1038/bmt.2009.364. Epub 2009 Dec 21.
The European Group for Blood and Marrow Transplantation has recently run a prospective, randomized trial comparing an early (3 months) vs a late (9 months) immunization program after allo-SCT with three doses of the conjugate 7-valent pneumococcal vaccine. This trial has shown that the response rate assessed 1 month after the third dose of conjugate vaccine was not inferior after an early vaccination vs a late vaccination. Part of the responder cohort of these patients (n=28) were chosen to assess the functionality of the anti-pneumococcal antibodies through an opsonophagocytic assay, 1 month after the third dose of conjugate vaccine. We have assessed the relationship between IgG titers measured by the pneumococcal ELISA and functional titers measured by opsonophagocytic assay of anti-pneumococcal antibodies. We found a significant correlation between titers for both assays, and conclude that the response to PCV7 after SCT induces functional antibodies.
欧洲血液和骨髓移植学会最近进行了一项前瞻性、随机试验，比较了同种异体造血干细胞移植后早期（3 个月）和晚期（9 个月）免疫接种方案，方案为三次接种结合 7 价肺炎球菌疫苗。该试验表明，在第三次接种结合疫苗后 1 个月评估的反应率，早期接种与晚期接种无差异。在这些患者的应答者队列中（n=28），一部分患者选择通过调理吞噬试验评估抗肺炎球菌抗体的功能，在第三次接种结合疫苗后 1 个月。我们评估了肺炎球菌酶联免疫吸附试验测量的 IgG 滴度与调理吞噬试验测量的抗肺炎球菌抗体功能滴度之间的关系。我们发现这两种检测方法的滴度之间存在显著相关性，并得出结论，SCT 后对 PCV7 的反应诱导了功能性抗体。
