通过无配体的铜催化级联过程来组装吲哚-2-羧酸酯。
Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.
机构信息
Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine, Health, Chinese Academy of Sciences, Guangzhou International Business Incubator D-10, Guangzhou Science Park, Guangzhou, 510663, China.
出版信息
Chem Commun (Camb). 2009 Dec 28(48):7581-3. doi: 10.1039/b918345k. Epub 2009 Nov 4.
DOI:10.1039/b918345k
PMID:20024286
Abstract
A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.
摘要
通过无配体的铜催化缩合/偶联/去甲酰化级联过程，从 2-卤代芳基醛或酮与乙基异氰酸乙酯直接合成了吲哚-2-羧酸酯。大多数 2-碘代、溴代和氯代底物在室温或温和条件下都能很好地进行反应。
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