胰岛素样生长因子结合蛋白-2 多肽片段自发可逆组装成荧光纳米管状结构。
Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures.
机构信息
NMR Research Centre, Indian Institute of Science, Bangalore-560012, India.
出版信息
Chem Commun (Camb). 2010 Jan 14;46(2):216-8. doi: 10.1039/b915775a. Epub 2009 Nov 12.
Abstract
In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.
摘要
在本通讯中，我们报告了胰岛素样生长因子结合蛋白（IGFBP-2）C 端结构域的多肽片段在体外自发和可逆地自我组装成数微米长的可溶性纳米管状结构，其机制涉及分子间二硫键，并表现出增强的荧光。
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