Reches Meital, Gazit Ehud
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Science. 2003 Apr 25;300(5619):625-7. doi: 10.1126/science.1082387.
Tubular nanostructures are suggested to have a wide range of applications in nanotechnology. We report our observation of the self-assembly of a very short peptide, the Alzheimer's beta-amyloid diphenylalanine structural motif, into discrete and stiff nanotubes. Reduction of ionic silver within the nanotubes, followed by enzymatic degradation of the peptide backbone, resulted in the production of discrete nanowires with a long persistence length. The same dipeptide building block, made of D-phenylalanine, resulted in the production of enzymatically stable nanotubes.
管状纳米结构被认为在纳米技术中有广泛的应用。我们报告了对一种非常短的肽（阿尔茨海默病β-淀粉样二苯基丙氨酸结构基序）自组装成离散且坚硬的纳米管的观察结果。纳米管内离子银的还原，随后肽主链的酶促降解，导致产生具有长持久长度的离散纳米线。由D-苯丙氨酸制成的相同二肽构建块产生了酶稳定的纳米管。
