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离子通道作为治疗靶点——CHI第四届年会

Ion Channels as Therapeutic Targets--CHI's Fourth Annual Conference.

作者信息

Thorneloe Kevin S

机构信息

GlaxoSmithKline plc, 709 Swedeland Road, King of Prussia, PA 19406, USA.

出版信息

IDrugs. 2010 Jan;13(1):16-9.

Abstract

The Ion Channels as Therapeutic Targets meeting, held in Boston, included topics covering new therapeutic developments in the field of ion-channel drug discovery. This conference report highlights selected presentations on sensory transient receptor potential channels, potassium-channel modulation, as well as methods for chloride-channel screening and channel occupancy evaluation. Human genetic mutations observed in channelopathies and methods to predict the cardiovascular safety of ion-channel modulators were also discussed.

摘要

在波士顿召开的“离子通道作为治疗靶点”会议涵盖了离子通道药物研发领域新治疗进展的诸多主题。本会议报告重点介绍了关于感觉瞬时受体电位通道、钾通道调节以及氯离子通道筛选和通道占有率评估方法的部分演讲内容。还讨论了在通道病中观察到的人类基因突变以及预测离子通道调节剂心血管安全性的方法。

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