Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119991, Russia.
J Biomed Mater Res B Appl Biomater. 2010 Apr;93(1):74-83. doi: 10.1002/jbm.b.31560.
Despite the numerous literature data available in the field of calcium phosphate bone cements, the mechanism and kinetics of their hardening, both of which are of great importance for cements application, in most cases, is unknown. In this work, the mechanism and kinetics of hardening of two novel high-strength calcium phosphate bone cements were studied using the energy dispersive X-ray diffraction technique, which allows rapid collection of the patterns. The phase transformations occurring on the setting and hardening processes were monitored in situ. Containing minimal quantity of components, whose mixing leads to the formation of cements with pH close to neutral, the cements under study are simple in handling. The main component of both formulations is tetracalcium phosphate. In both cements, the effect of the addition of high- and low-molecular weight chitosan on phase development and kinetics was investigated in detail. One of the cements has the compressive strength of about 70 MPa, whereas the strength of the other, containing Ca(3)Al(2)O(6), is much higher, about 100 MPa. This latter cement could be regarded as an alternative to the common low-strength bioresorbable brushite cements.
尽管在磷酸钙骨水泥领域有大量的文献资料，但它们的硬化机理和动力学（对于水泥的应用都非常重要）在大多数情况下仍然未知。在这项工作中，使用能量色散 X 射线衍射技术研究了两种新型高强度磷酸钙骨水泥的硬化机理和动力学，该技术允许快速收集图谱。在凝固和硬化过程中监测了发生的相转变。研究用的水泥中各成分的含量很少，混合后形成接近中性 pH 值的水泥，操作简单。两种配方的主要成分都是磷酸四钙。在这两种水泥中，详细研究了添加高分子量和低分子量壳聚糖对相发展和动力学的影响。其中一种水泥的抗压强度约为 70MPa，而另一种含有 Ca(3)Al(2)O(6)的水泥强度则要高得多，约为 100MPa。这种水泥可以作为常见的低强度生物可吸收的羟磷灰石水泥的替代品。
