区域选择性卤化反应以及随后的双环 2-吡啶酮的铃木-宫浦偶联反应。
Regioselective halogenations and subsequent Suzuki-Miyaura coupling onto bicyclic 2-pyridones.
机构信息
Department of Chemistry, Umeå University, SE-901 80 Umeå, Sweden.
出版信息
J Org Chem. 2010 Feb 5;75(3):972-5. doi: 10.1021/jo902458g.
PMID:20025251
Abstract
A selective synthesis of 6-bromo-8-iodo dihydro thiazolo ring-fused 2-pyridones is described. These halogenated 2-pyridones are selectively arylated by sequential Suzuki-Miyaura couplings. This approach can advantageously be used to synthesize focused libraries of substituted ring-fused 2-pyridones, a class of compounds with novel antibacterial properties.
摘要
描述了 6-溴-8-碘二氢噻唑并环并 2-吡啶酮的选择性合成。这些卤代 2-吡啶酮可以通过顺序的 Suzuki-Miyaura 偶联反应选择性芳基化。这种方法可以有利地用于合成取代的环并 2-吡啶酮的聚焦文库，这是一类具有新型抗菌性质的化合物。
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