钴（III）催化吡啶酮和异喹啉酮的位点选择性C-H酰胺化反应。
Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones.
作者信息
Gao Feng, Han Xu, Li Chunpu, Liu Lingjun, Cong Zhanqing, Liu Hong
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 China.
Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 China.
出版信息
RSC Adv. 2018 Sep 21;8(57):32659-32663. doi: 10.1039/c8ra06716c. eCollection 2018 Sep 18.
In this study, Cp*Co(iii)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This approach features mild conditions, high efficiency and good functional tolerance. Furthermore, gram-scale preparation and preliminary mechanism experiments were carried out. It provides a straightforward approach for the direct modification of pyridone derivatives.
本研究报道了使用恶唑酮作为酰胺化试剂，Cp*Co(iii)催化吡啶酮和异喹啉酮的位点选择性酰胺化反应。该方法具有条件温和、效率高和官能团耐受性好的特点。此外，还进行了克级规模的制备和初步的机理实验。它为吡啶酮衍生物的直接修饰提供了一种简便的方法。
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