Division of Infectious Diseases, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Clin Infect Dis. 2010 Jan 15;50(2):247-54. doi: 10.1086/649540.
Bacterial enteric infections cause substantial morbidity in the United States both from acute illness and sequelae that follow. Reactive arthritis (ReA) is a poorly defined term that is used to describe a variety of rheumatologic phenomena that may occur after Salmonella, Shigella, Campylobacter, and Yersinia infection, as well as other types of infections (eg, Chlamydia). This review focuses on clinical and epidemiologic investigations of ReA following bacterial enteric infection in the United States. Only 2 population-based studies of ReA following enteric infection have been performed in the United States. ReA following outbreaks of Campylobacter and Yersinia infection has not been studied, and investigations following Shigella and Salmonella outbreaks have focused primarily on the more narrowly defined, but now outdated, concept of "Reiter's syndrome" rather than ReA. Additional epidemiologic studies are needed to determine the burden of illness due to ReA following enteric infection, but a clearer definition of the term is a prerequisite.
细菌性肠道感染会导致大量的发病率，包括急性疾病和随后的后遗症。反应性关节炎（ReA）是一个定义不明确的术语，用于描述在沙门氏菌、志贺氏菌、弯曲杆菌和耶尔森氏菌感染以及其他类型感染（如衣原体）后可能发生的各种风湿学现象。本篇综述重点关注美国细菌性肠道感染后反应性关节炎的临床和流行病学研究。在美国，仅进行了两项关于肠道感染后反应性关节炎的基于人群的研究。对弯曲杆菌和耶尔森氏菌感染暴发后的反应性关节炎尚未进行研究，而对志贺氏菌和沙门氏菌暴发后的研究主要集中在更狭义但现已过时的“赖特综合征”概念上，而不是反应性关节炎。需要进一步开展流行病学研究来确定肠道感染后反应性关节炎的疾病负担，但明确术语的定义是前提条件。
